See this page and the instructions below. If you want further details, here is the support page for each model: The short version is, all current and some discontinued ScanSnap models will be supported. Follow the Online Update Instructions or see the support page for your model. Update : The ScanSnap El Capitan update has now been released. Usually they give a time frame when the update will be out, but not this time. I’ve done some searching and haven’t come across any concrete problems yet, but at the time of writing a new version of ScanSnap Manager with official El Capitan support has not been released. If you’ve made the El Capitan upgrade, please leave a comment below with how it is working out for you. Whenever a new version of an operating system is released, I put up a post to collect experiences and resources for the ScanSnap.